Global Health Ethics

Cases in Bioethics: Health Research Ethics in Southeast Asia

A comprehensive, accessible collection of health research case studies emphasizing regional ethical challenges in Southeast Asia.

Lead editors Joseph Ali (Johns Hopkins Berman Institute of Bioethics) and Nishakanthi Gopalan (Universiti Malaya) collaboratively created this groundbreaking resource on health research ethics in Southeast Asia.

To navigate the compilation using a search bar to rapidly identify cases across a range of topics, visit the Casebook page on the JHU Press website.

With contributions by researchers and ethicists from the region, this case compilation emphasizes global cooperation and a commitment to addressing real-world ethical dilemmas in health research, particularly in low- and middle-income countries. This resource vividly illustrates the ethical challenges prevalent in regional health research, including those faced by researchers, participants, institutions, and policymakers.

  Title Authors
1 A Clinical Trial Involving People with Memory Impairments Julia Patrick Engkasan, Mazlina Mazlan, Nishakanthi Gopalan, Tivyashinee
2 A Clinical Trial to Compare Orthodontic Retainers Wan Nurazreena Wan Hassan, Norhidayah Mohd Tahir
3 A Cross-Sectional Study of the Impact of Online Dental Education during the Pandemic Anand Marya
4 A Prospective Study on Immune Response of a COVID-19 Vaccine Booster Robert Sinto
5 A Qualitative Study of Stimulant-Using Men Who Have Sex with Men Howie Lim Sin How
6 A Randomized Study of Prison-Based Methadone Maintenance Therapy Rumana Saifi
7 A Remote Survey of HPV Stigma during the COVID-19 Pandemic Ch’ng Wan Ping, Rumana Saifi
8 A Weight Reduction Intervention for Adolescent Students Roli Mathur, Manikandan S
9 Accessing a Novel Cancer Therapy Ch’ng Wan Ping
10 An HIV Self-Testing Intervention to Promote HIV Testing among Key Populations Teong Win Zee, Rumana Saifi
11 An International Industry-Sponsored Trial to Prolong Life Expectancy of Liver Failure Patients Harnawan Rizki, Chin Kuen Yei, Ch’ng Wan Ping, Rumana Saifi
12 Asthma Research in the Emergency Department Hafizah Binti Zainal Abidin, Amnah binti Azahar
13 Awareness of Animal Welfare Suzita Mohd Noor, Durriyyah Sharifah Hasan Adli
14 Awareness, Knowledge, Attitudes, and Use of E-Cigarettes in School-Aged Children Nor Adinar Baharuddin
15 Better Mice in Corridors Than Mice in the Rooms! Suzita Mohd Noor, Durriyyah Sharifah Hasan Adli
16 Biobanking of Specimens from Children Hans Prakash Sathasivam
17 Breach Of Confidentiality via Social Media Suzita Mohd Noor, Rozaida Poh Yuen Ying
18 Challenges with Tooth Donations for Research Lim Ghee Seong, Hayati Ishak, Arilatha Arimuthu
19 Clinical Trial of a Novel Therapeutic with Critically Ill Patients during a Pandemic Ch’ng Wan Ping
20 Co-enrollment of Patients in Research Involving Tissue Collection Maylene Tan Zipagan
21 Comparing Two Drugs to Prevent Postpartum Hemorrhage Siti Fatimah Zahra Mohd Anuar, Fatihah Mahmud, Norizan Rosli
22 Conducting a Vaccine Trial with Adolescents during a Pandemic Chong Lee Ai
23 Conducting Research with People Who Inject Drugs during the COVID-19 Pandemic Nur Afiqah Mohd Salleh
24 Conducting School-Based Mental Health Research Hu Mi, Esther Luo, Laura Bothwell, Kaveh Khoshnood
25 Continued Access to Treatment for Patients Withdrawing from Clinical Trials Nishakanthi Gopalan, Julia Patrick Engakasan, Tivyashinee, Phan Chia Wei
26 Delivery of Preexposure Prophylaxis (PrEP) for Men Who Have Sex with Men Iskandar Shah Raja Azwa, Rumana Saifi
27 Designing an mHealth App for HIV Prevention Jeffrey Ralph B Luces, Rumana Saifi
28 Dietary Supplementation for Prepubertal Children in Urban Public Schools Erwin Jiayuan Khoo, Winnie Siew Swee Chee
29 Drug Use and Risk of HIV and Other Blood-Borne Infections among Climate-Induced Migrants Kaveh Khoshnood, Laura Bothwell
30 Effect of Mutations in Atrial Septal Defect Patients Roslina Husaini, Nur Liana Md Nasir, Norizan Rosli
31 Evaluation of a Minimal Risk Research Protocol by a Research Ethics Subcommittee Nur Khairul Bariyyah Mohd Hatta, Lai Wei Hong, Norizan Rosli
32 Fair Sharing of Benefits in Research Involving Human Biological Materials Chin Kuen Yei, Harnawan Rizki, Rumana Saifi
33 Genetic Material Sampling from an Indigenous Community Yi Xian Er, Kuen Yei Chin, Mohammad Firdaus Abdul Aziz, Kee Seong Ng
34 Health Professionals’ Perspectives on Counseling Patients about Congenital Disorders and Abortion Dan Luo, Yanlin Liu, Esther Luo, Laura Bothwell, Kaveh Khoshnood
35 Human Biobanking Research in Low- and Middle-Income Countries Kuen Yei Chin, Mohammad Firdaus Abdul Aziz, Kee Seong Ng, Yi Xian Er, Charles Li Qi Gunn
36 Integrating Research Ethics into an Undergraduate Medical Curriculum Lui Sze Chiang, Rumana Saifi
37 Investigating Opinions on Emerging Science and Technology Angelina Olesen
38 Lottery Incentives in HIV Research Alex Phang Kean Chang
39 Managing Bruxism in Children with Cerebral Palsy Ilham Wan Mokhtar
40 Manufacturing Reliable Rapid Antibody Test Kits for the Investigation of Infectious Diseases Erwin Khoo
41 Musculoskeletal Steroid Injection for Pain Management during COVID-19 Azwan Aziz, Azmi Mohamad Nahar
42 Newborn Screening for Detection of Inherited Diseases Ebner Bon G. Maceda, Mary Ann R. Abacan, Mary Anne D. Chiong, Catherine Lynn T. Silao, Maria Melanie Liberty B. Alcausin
43 Patient Perceptions of Privacy During Behavioral Monitoring in Psychiatric Wards Nasriah Zakaria, Rusyaizila Ramli
44 Permission and Assent among Children during Clinical Research Lui Sze Chiang, Azanna Ahmad Kamar, Nishakanthi Gopalan, Asiah Kassim
45 Permission and Assent for Research with Children Who Have Cerebral Palsy Leow Mei Lian, Phei Ming Chern
46 Pregnant Women as Research Participants: a Study on HPV Self-Sampling Ch’ng Wan Ping, Rumana Saifi
47 Prevalence of Military Sexual Trauma among Military Personnel Hong Chuan Loh, Chirk Jenn Ng
48 Private Cord Blood Stem Cell Banking Mohammad Firdaus Bin Abdul Aziz, Nishakanthi Gopalan, Kee Seong Ng, Phang Kean Chang, Kuen Yei Chin
49 Reconsent for Biobanking During a Pandemic Tiong Xun Ting, Siti Nur Syahirah Morshidi, Lai Wei Hong Lai, Shirin Tan Hui, Hans Prakash Sathasivam
50 Reproductive and Mental Health in Female Refugees Wan Rosalina Wan Rosli
51 Research Involving Pregnant Adolescents in Southeast Asia Aimi Nadia Mohd Yusof, Amirah Abdul Rahman, Thuhairah Hasrah, Abdul Rahman, Suraya Abdul Razak
52 Returning Cancer Genomic Research Results to Participants Meow-Keong Thong, Sok-Kun Tae, Rifhan Azwani Mazlan
53 Rights and Protections for Clinical Research Staff Norizan Rosli, Nur Ain Zahidah
54 Role of BRCA1 and BRCA 2 in Hereditary Breast Cancer Risk Sok-Kun Tae, Meow-Keong Thong, Rifhan Azwani Mazlan
55 Scaling Up HIV Self-Testing in a Heterogeneous Setting Teong Win Zee, Rumana Saifi
56 Stability of Postorthodontic Treatment in Patients with Bimaxillary Proclination Norhidayah Mohd Tahir, Wan Nurazreena Wan Hassan
57 Stigma in Health Care Settings Experienced by Key Populations Asfarina Amir Hassan, Rumana Saifi, Wong Pui Li, Valerie Earnshaw
58 Strengthening the Legal and Regulatory Framework for Research Involving Biobanks in Malaysia Amnah Azahar, Hafizah Zainal Abidin, Aimi Nadia Mohd Yusof
59 Studying the Impact of the COVID-19 Pandemic on the Rohingya Community in Kuala Lumpur Raudah Mohd Yunus, Chen Xin Wee, Ely Zarina Samsudin, Aimi Nadia Mat Ruzlin
60 Supplementing Micronutrients in Children under 3 Years Old Chong Lee Ai
61 Testing a Wobble Board for Fall Prevention in Older People Mei Lian Leow, Phei Ming Chern
62 Unauthorized Use of Lab Equipment for Research Purposes Roslina Husaini, Nur Liana Md Nasir, Norizan Rosli
63 Welfare of Researchers in an Infectious Disease Study Alex Phang Kean Chang

This case compilation was created by the Master of Health Research Ethics (MOHRE) Program, a collaboration of the Universiti Malaya and the Johns Hopkins Berman Institute of Bioethics, with funding from the U.S. National Institutes of Health (NIH), Fogarty International Center (Grant R25TW010891). Additional editorial support was provided by senior editors Jeremy Sugarman and Adeeba Kamarulzaman, along with Julia Patrick Engkasan, Rumana Saifi and Alison Davis. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Published by Johns Hopkins University Press.

Resource DOI: https://doi.org/10.1353/resource.5

Citation: View Resource Citation