- Core Faculty
Berman Institute of Bioethics - Associate Professor
Johns Hopkins School of Medicine
Dr. Unguru is a pediatric hematologist/oncologist with joint faculty appointments at The Herman and Walter Samuelson Children’s Hospital at Sinai and The Johns Hopkins Berman Institute of Bioethics, where he is a Core Faculty member. He is also Associate Professor in the School of Medicine, Johns Hopkins University. Dr. Unguru’s research interests include clinical and research ethics. His scholarship and publications have focused on the role of children and providers in facilitating shared decision-making, end-of-life decision-making, allocation of scarce lifesaving medications, and ethics education. Dr. Unguru has served as an ethics consultant to national organizations, including the American Academy of Pediatrics, the American Medical Association, the Food and Drug Administration, and the US Senate Committee on Homeland Security and Governmental Affairs. He is on the Editorial Board of Pediatric Ethicscope and serves as a peer reviewer for leading academic medical journals. Dr. Unguru is Chair of the Children’s Oncology Group, Bioethics Steering Committee. Dr. Unguru implemented and directs a clinical ethics curriculum for the pediatric house staff at The Herman and Walter Samuelson Children’s Hospital at Sinai. Dr. Unguru is the Chairman of the Ethics Committee at Sinai Hospital of Baltimore. Dr. Unguru leads a multidisciplinary, transnational working group examining the ethical and policy implications of chemotherapy shortages in childhood cancer.
Research Interests
- Pediatric bioethics
- Clinical ethics
- Research ethics
Education
- Greenwall Fellowship in Bioethics and Public Policy, Johns Hopkins University
- Pediatric Hematology/Oncology Fellowship, Children’s National Medical Center
- Pediatric Residency, The Children’s Hospital at Sinai
- MD, Technion- Israel Institute of Technology/ Bruce Rappaport Faculty of Medicine
- MS, Touro College/ Barry Z. Levine School of Health Sciences
- MA, University of Maryland, Baltimore County
- BA, University of Maryland, Baltimore County
Activities
- Chairman, Sinai Hospital Ethics Committee
- Chair, Children’s Oncology Group Steering Committee on Bioethics
- Chairman, Scholarly Activity Committee, Department of Pediatrics, The Herman & Walter Samuelson Children’s Hospital at Sinai
- Member, Sinai Hospital Medical Executive Committee
- Member, Editorial Board, Pediatric Ethicscope
- Medical Director, Horizon Day Camp, Baltimore
Recent Publications
- Fox E, Unguru Y. Oncology drug shortagess in the USA – business as usual. Nat Rev Clin Oncol (2019) doi:10.1038/s41571-019-0318-x.
- Shuman A, Unguru Y. Drug shortages: The view across an ocean. Oncologist. 2020;25:1-3
- Unguru Y. Balancing risk and reward: Greater research oversight is appropriate for novel therapies for children with life-limiting illness. Am J Bioeth. 2020;20(4):104-105.
- Ehmann MR, Zink EK, Levin A, Suarez JI, … Unguru Y, et al. Operational recommendations for scarce resource allocation in a public health crisis. Chest. 2020 Sep 28;S0012-3692(20)34804-2. https://doi.org/10.1016/j.chest.2020.09.246.
- Unguru Y. Confronting medication scarcity in the era of COVID-19: Clinical Ethics. 2020 Nov. https://doi.org/10.1177%2F1477750920977096.
- Unguru Y. Culturally aware communication promotes ethically sensitive care. Am J Bioeth. 2022;22(6):31-33.
- Benedetti D, Marron J, Thomas S, Caruso Brown A, … Unguru Y. Words matter. J Clin Oncol. 2022. Sep 23:JCO2201056. doi: 10.1200/JCO.22.01056.
- Benedetti D, Marron J, Thomas S, Caruso Brown A, … Unguru Y., Kodish E. The role of ethicists in pediatric hematology/oncology: Current status and future needs. Pediatr Blood Cancer. 2022;e30312. https://doi.org/10.1002/pbc.30312
- Sharma A, Young A, Carroll Y, Darji H, … Unguru Y, et al. Gene therapy in sickle cell disease: Attitudes and Informational needs of patients and caregivers. Pediatric Blood and Cancer. 2923;e30319. https://doi-org.proxy1.library.jhu.edu/10.1002/pbc.303
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Unguru Y, Bernhardt MB, Berg SL, Johnson LM, Pyke-Grimm K, Woodman C, Fernandez CV. Position Paper – Chemotherapy and Supportive Care Agents are Essential Medicines for Children with Cancer. JAMA Pediatr. Doi:10.1001/jamapediatrics.2019.0070.
- Unguru Y. Comment on: Adolescent Patient Involvement in Discussions about Relapsed or Refractory Cancer with Oncology Clinicians. Pediatric Blood and Cancer. 2018;e27043. doi.org/10.1002/pbc.27043.
- Unguru Y. Funerals. Pediatric Blood and Cancer. 2018;e27059. Doi: 10.1002/pbc.27059. [Epub ahead of print].
- Sharma A, Caruso Brown A, Johnson LM, Unguru Y, Lantos J. An Extragavant Gift from a Grateful Patient. Pediatrics. 2018;141(6):e20172837.
- Barone S, Unguru Y. Ethical Issues around Pediatric Death: Navigating Consent, Assent, and Disagreement Regarding Life-Sustaining Medical Treatment. Child and Adolescent Psychiatric Clinics. 2018 Oct;27(4):539-550.
- Unguru, Y. Speed and Safety in Drug Approval and Commercialization. Pediatrics. November 2017.
- Barone S, Unguru Y. Should Euthanasia be Considered Iatrogenic? AMA J Ethics.2017;19(8):802-814.
- Unguru Y. Comment on: Contributing Factors and Outcomes of Treatment Refusal in Pediatric Oncology in Germany. Pediatric Blood and Cancer 2017;64(2):395.
- Unguru Y, Fernandez CV, Bernhardt B, Berg S, Pyke-Grimm K, Woodman C, Joffe S. An Ethical Framework for Allocating Scarce Life-saving Chemotherapy and Supportive Care Drugs for Childhood Cancer. JNCI. 2016;108(6):1-7
- Unguru Y. Chemotherapy Shortages: When is Enough Enough? Journal of Clinical Pathways. 2016:2(4), 26-29.
- Johnson Liza-Marie, Unguru Y. Recruiting Children for Clinical Trials: Lessons from Pediatric Oncology. American Journal of Bioethics. 2015:15(11), 1–3
- Unguru Y. Ethical Challenges in Early-Phase Pediatric Research for Life-Limiting Illness. Seminars in Pediatric Neurology. 2015;22(3):177-186.
- Simon C, Kodish E, Unguru Y. Cancer, Ethical Issues Related to Diagnosis and Treatment. Bioethics, 4th Edition. Edited by Bruce Jennings. Farmington Hills, MI: Macmillan Reference USA, 2014
- DeCamp M, Joffe S, Fernandez CV, Faden RR, Unguru Y. Consensus Statement of the Working Group on Chemotherapy Drug Shortages in Pediatric Oncology. Pediatrics. 2014;133:1-9.
- Unguru Y, Joffe Steven, Fernandez Conrad V, Yu A. Ethical Issues for Control arm Patients after Revelation of Benefits of Experimental Therapy. A Framework Modeled in Neuroblastoma. JCO. 2013;31(5):641-646.
- Unguru Y. Decision-making for Children with Life-limiting Illnesses: A Clinical Approach. Journal of Health Care Law & Policy. 2012;15(1):117-128.
- Unguru Y. Making Sense of Adolescent Decision-making: Challenge and Reality. In: Silber T, English eds. Ethical and Legal Issues in the Care of Adolescents. Adolescent Medicine State of the Art Reviews. 2011;22(2):195-206.
- Unguru Y. The Successful Integration of Research and Care: How Pediatric Oncology Became the Subspecialty in which research Defines the Standard of Care. Pediatric Blood and Cancer 2011;56:1019-1025.
- Unguru Y., Sill A, Kamani N. The Experiences of Children Enrolled in Pediatric Oncology Research: Implications for Assent. Pediatrics 2010;125:e876-e883.
- Unguru Y., Coppes MJ, Kamani N. Rethinking Pediatric Assent: From Requirement to Ideal. Pediatric Clinics of North America 2008;55(1):215-226.
- Unguru Y. Children’s Views on their Involvement in Clinical Research. A Comment. Pediatric Blood and Cancer 2008:51(5):716-717.